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Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography.

Identifieur interne : 002310 ( Main/Exploration ); précédent : 002309; suivant : 002311

Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography.

Auteurs : Shiming Li [États-Unis] ; Ted Lambros ; Zhenyu Wang ; Robert Goodnow ; Chi-Tang Ho

Source :

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [ 1570-0232 ] ; 2007.

RBID : pubmed:17035106

English descriptors

KwdEn :
- Chromatography, High Pressure Liquid, Chromatography, Supercritical Fluid (methods), Citrus sinensis (chemistry), Flavones (isolation & purification), Magnetic Resonance Spectroscopy, Spectrometry, Mass, Electrospray Ionization.
MESH :
- chemical , isolation & purification : Flavones.
- chemistry : Citrus sinensis.
- methods : Chromatography, Supercritical Fluid.
- Chromatography, High Pressure Liquid, Magnetic Resonance Spectroscopy, Spectrometry, Mass, Electrospray Ionization.

Abstract

Polymethoxyflavones (PMFs) from citrus genus are of particular interest because of their broad spectrum of biological activities, such as anti-inflammatory, anti-carcinogenic, and anti-atherogenic properties. Recently, the exploration into the beneficial health properties of PMFs in citrus fruits has dramatically increased. However, the supply of pure PMFs in the in vivo study is a limiting factor due to the difficulties in large-scale isolation of the interested PMFs. Therefore, the development of an efficient and a scalable separation method of PMFs is necessary and significant. In this paper, we report a newly developed method for efficient and relatively large-scale isolation of four PMFs from sweet orange (Citrus sinensis) peel by employing supercritical chromatography (SFC): nobiletin, tangeretin, 3,5,6,7,8,3',4'-heptamethoxyflavone and 5,6,7,4'-tetramethoxyflavone.

DOI: 10.1016/j.jchromb.2006.09.010
PubMed: 17035106

Affiliations:

Le document en format XML

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<author><name sortKey="Li, Shiming" sort="Li, Shiming" uniqKey="Li S" first="Shiming" last="Li">Shiming Li</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Drug Discovery, Hoffmann-La Roche Inc., Nutley, NJ 07110, USA. shiming.li@roche.com</nlm:affiliation>
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<author><name sortKey="Wang, Zhenyu" sort="Wang, Zhenyu" uniqKey="Wang Z" first="Zhenyu" last="Wang">Zhenyu Wang</name>
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<author><name sortKey="Goodnow, Robert" sort="Goodnow, Robert" uniqKey="Goodnow R" first="Robert" last="Goodnow">Robert Goodnow</name>
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<front><div type="abstract" xml:lang="en">Polymethoxyflavones (PMFs) from citrus genus are of particular interest because of their broad spectrum of biological activities, such as anti-inflammatory, anti-carcinogenic, and anti-atherogenic properties. Recently, the exploration into the beneficial health properties of PMFs in citrus fruits has dramatically increased. However, the supply of pure PMFs in the in vivo study is a limiting factor due to the difficulties in large-scale isolation of the interested PMFs. Therefore, the development of an efficient and a scalable separation method of PMFs is necessary and significant. In this paper, we report a newly developed method for efficient and relatively large-scale isolation of four PMFs from sweet orange (Citrus sinensis) peel by employing supercritical chromatography (SFC): nobiletin, tangeretin, 3,5,6,7,8,3',4'-heptamethoxyflavone and 5,6,7,4'-tetramethoxyflavone.</div>
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<country name="États-Unis"><region name="New Jersey"><name sortKey="Li, Shiming" sort="Li, Shiming" uniqKey="Li S" first="Shiming" last="Li">Shiming Li</name>
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Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography.

Efficient and scalable method in isolation of polymethoxyflavones from orange peel extract by supercritical fluid chromatography.

Source :

English descriptors

Abstract

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Le document en format XML

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